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bml111  (R&D Systems)


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    Structured Review

    R&D Systems bml111
    Debris was implanted and the calvarial bone of mice were then treated with <t>BML111</t> (1 mg/kg), WRW4 (2.5 mg/kg) and Ac2–26 (1 mg/kg). a Quantification of the lytic area in calvarial bone tissues analyzed by micro-CT. Results represent the mean ± SEM of 7 mice. b , c Quantification of TRAP-stained areas and inflammatory infiltrate in calvarial bone tissues. Significant difference among the groups was determined by one-way ANOVA, followed by Tukey’s multiple-comparison procedure. * p < 0.05, ** p < 0.001, *** p < 0.0001, **** p < 0.00001. ns indicates no significant difference. d Representative images for micro-CT and histological observations of bone sections stained by TRAP and H&E. Scale bar 100 µm. Source data are provided as a Source Data file.
    Bml111, supplied by R&D Systems, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/bml111/pmc09262976-285-18-19?v=R%26D+Systems
    Average 92 stars, based on 1 article reviews
    bml111 - by Bioz Stars, 2026-08
    92/100 stars

    Images

    1) Product Images from "Inhibitory role of Annexin A1 in pathological bone resorption and therapeutic implications in periprosthetic osteolysis"

    Article Title: Inhibitory role of Annexin A1 in pathological bone resorption and therapeutic implications in periprosthetic osteolysis

    Journal: Nature Communications

    doi: 10.1038/s41467-022-31646-0

    Debris was implanted and the calvarial bone of mice were then treated with BML111 (1 mg/kg), WRW4 (2.5 mg/kg) and Ac2–26 (1 mg/kg). a Quantification of the lytic area in calvarial bone tissues analyzed by micro-CT. Results represent the mean ± SEM of 7 mice. b , c Quantification of TRAP-stained areas and inflammatory infiltrate in calvarial bone tissues. Significant difference among the groups was determined by one-way ANOVA, followed by Tukey’s multiple-comparison procedure. * p < 0.05, ** p < 0.001, *** p < 0.0001, **** p < 0.00001. ns indicates no significant difference. d Representative images for micro-CT and histological observations of bone sections stained by TRAP and H&E. Scale bar 100 µm. Source data are provided as a Source Data file.
    Figure Legend Snippet: Debris was implanted and the calvarial bone of mice were then treated with BML111 (1 mg/kg), WRW4 (2.5 mg/kg) and Ac2–26 (1 mg/kg). a Quantification of the lytic area in calvarial bone tissues analyzed by micro-CT. Results represent the mean ± SEM of 7 mice. b , c Quantification of TRAP-stained areas and inflammatory infiltrate in calvarial bone tissues. Significant difference among the groups was determined by one-way ANOVA, followed by Tukey’s multiple-comparison procedure. * p < 0.05, ** p < 0.001, *** p < 0.0001, **** p < 0.00001. ns indicates no significant difference. d Representative images for micro-CT and histological observations of bone sections stained by TRAP and H&E. Scale bar 100 µm. Source data are provided as a Source Data file.

    Techniques Used: Micro-CT, Staining, Comparison



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    Debris was implanted and the calvarial bone of mice were then treated with <t>BML111</t> (1 mg/kg), WRW4 (2.5 mg/kg) and Ac2–26 (1 mg/kg). a Quantification of the lytic area in calvarial bone tissues analyzed by micro-CT. Results represent the mean ± SEM of 7 mice. b , c Quantification of TRAP-stained areas and inflammatory infiltrate in calvarial bone tissues. Significant difference among the groups was determined by one-way ANOVA, followed by Tukey’s multiple-comparison procedure. * p < 0.05, ** p < 0.001, *** p < 0.0001, **** p < 0.00001. ns indicates no significant difference. d Representative images for micro-CT and histological observations of bone sections stained by TRAP and H&E. Scale bar 100 µm. Source data are provided as a Source Data file.
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    Debris was implanted and the calvarial bone of mice were then treated with <t>BML111</t> (1 mg/kg), WRW4 (2.5 mg/kg) and Ac2–26 (1 mg/kg). a Quantification of the lytic area in calvarial bone tissues analyzed by micro-CT. Results represent the mean ± SEM of 7 mice. b , c Quantification of TRAP-stained areas and inflammatory infiltrate in calvarial bone tissues. Significant difference among the groups was determined by one-way ANOVA, followed by Tukey’s multiple-comparison procedure. * p < 0.05, ** p < 0.001, *** p < 0.0001, **** p < 0.00001. ns indicates no significant difference. d Representative images for micro-CT and histological observations of bone sections stained by TRAP and H&E. Scale bar 100 µm. Source data are provided as a Source Data file.
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    Debris was implanted and the calvarial bone of mice were then treated with <t>BML111</t> (1 mg/kg), WRW4 (2.5 mg/kg) and Ac2–26 (1 mg/kg). a Quantification of the lytic area in calvarial bone tissues analyzed by micro-CT. Results represent the mean ± SEM of 7 mice. b , c Quantification of TRAP-stained areas and inflammatory infiltrate in calvarial bone tissues. Significant difference among the groups was determined by one-way ANOVA, followed by Tukey’s multiple-comparison procedure. * p < 0.05, ** p < 0.001, *** p < 0.0001, **** p < 0.00001. ns indicates no significant difference. d Representative images for micro-CT and histological observations of bone sections stained by TRAP and H&E. Scale bar 100 µm. Source data are provided as a Source Data file.
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    Image Search Results


    Debris was implanted and the calvarial bone of mice were then treated with BML111 (1 mg/kg), WRW4 (2.5 mg/kg) and Ac2–26 (1 mg/kg). a Quantification of the lytic area in calvarial bone tissues analyzed by micro-CT. Results represent the mean ± SEM of 7 mice. b , c Quantification of TRAP-stained areas and inflammatory infiltrate in calvarial bone tissues. Significant difference among the groups was determined by one-way ANOVA, followed by Tukey’s multiple-comparison procedure. * p < 0.05, ** p < 0.001, *** p < 0.0001, **** p < 0.00001. ns indicates no significant difference. d Representative images for micro-CT and histological observations of bone sections stained by TRAP and H&E. Scale bar 100 µm. Source data are provided as a Source Data file.

    Journal: Nature Communications

    Article Title: Inhibitory role of Annexin A1 in pathological bone resorption and therapeutic implications in periprosthetic osteolysis

    doi: 10.1038/s41467-022-31646-0

    Figure Lengend Snippet: Debris was implanted and the calvarial bone of mice were then treated with BML111 (1 mg/kg), WRW4 (2.5 mg/kg) and Ac2–26 (1 mg/kg). a Quantification of the lytic area in calvarial bone tissues analyzed by micro-CT. Results represent the mean ± SEM of 7 mice. b , c Quantification of TRAP-stained areas and inflammatory infiltrate in calvarial bone tissues. Significant difference among the groups was determined by one-way ANOVA, followed by Tukey’s multiple-comparison procedure. * p < 0.05, ** p < 0.001, *** p < 0.0001, **** p < 0.00001. ns indicates no significant difference. d Representative images for micro-CT and histological observations of bone sections stained by TRAP and H&E. Scale bar 100 µm. Source data are provided as a Source Data file.

    Article Snippet: For examining the therapeutic effects of AnxA1, eight-week-old male C57/BL6 mice was treated by N-terminal AnxA1 (Ac2–26) or BML111 (R&D Systems) was injected 5 times at a concentration of 1 mg/kg.

    Techniques: Micro-CT, Staining, Comparison